The Leibniz Institute of Virology (LIV) is an independent research institution for basic biomedical research. As a foundation under civil law and member of the Leibniz Association, the Institute occupies a leading position both nationally and internationally.
The BMBF research group Genomics of Retroviral Infection, headed by Dr. Ulrike Lange, focuses on the biology of human exogenous and endogenous retroviruses and on development of approaches to control retroviral infections. The group uses a wide range of experimental methods combined with computational biology approaches to address research questions that span from basic to translational science. In recent work, we have characterized the signature of human endogenous retrovirus (HERV) activity at locus-level resolution in primary T cells (Hamann et al., 2023, BMC Medical Genomics). We are currently actively exploring how this signature is impacted upon in HIV-1 infection, which has been reported to induce global HERV activation. The project will focus on functional studies to dissect HERV regulated or modulated pathways in infected and bystander CD4 T cells, to better understand how transposable elements are shaping immune responses in HIV-1 infection. The project will involve experimental laboratory work, including a range of molecular biology techniques, genetic engineering/kd/ko studies in primary T cells and generation and analysis of transcriptomics and epigenomics datasets amongst other.
We are looking for a highly motivated, ambitious and team-oriented candidate for a
Postdoc position (f/m/x)
The role of transposable elements in shaping immune responses in HIV-1 infection
The position is initially limited for 2 years with starting date 1st quartile of 2025.
The LIV is certified with the Total Equality distinction, and promotes work-life balance and professional equality between employees of all sex and genders. Severely disabled persons will be given preferential consideration if their suitability, qualifications, and professional performance are otherwise equal.
Your application should include a letter of motivation, CV, short description of previous research projects and technical expertise, names and contact details of two referees and your certificates. We look forward to receiving your application in English language until the 15th November 2024. Until the position is filled, applications received at a later date may be considered.
Would you like to shape the future with us? Then we look forward to receiving your application!